chromosome 3 open reading frame 52Genealiases: HYPT15 · TTMP
Q-omics provides the consensus-scored C3orf52 profile across patient tissues and cancer cell-line models. C3orf52 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, C3orf52 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, C3orf52 RNA expression shows 18,833 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight HNSC, KIRC, and UVM as cancer lineages where C3orf52 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for C3orf52 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes C3orf52 survival associations across molecular data types. C3orf52 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (3) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible C3orf52 RNA expression–survival associations across cancer types. High C3orf52 expression shows unfavorable associations in HNSC, LGG, KIRP, LIHC and THCA, but favorable associations in KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for C3orf52 RNA expression.
This table summarizes C3orf52 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for C3orf52. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. C3orf52 shows lower tumor expression in KIRC, THCA, KICH and KIRP and higher tumor expression in HNSC and BRCA. The KIRC box plot shows higher C3orf52 RNA expression in normal versus tumor tissue (log2 FC = −1.990, t-test p < 0.001).
This table shows molecular features associated with C3orf52 in patient tissues and cancer cell lines. In patient samples, C3orf52 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, C3orf52 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BREAST, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BONE.
