C3orf52

Across TCGA patient cohorts, C3orf52 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf52-associated genes across cancer lineages are p62 Lck ligand, PCNA, and PDCD4. Each is linked with C3orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf52-to-partner and partner-to-C3orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by C3orf52-low versus C3orf52-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf52→partner) and Y-score (partner→C3orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.367	+2.000	.012	.032	3	1
UCEC	PCNA →	+0.203	+3.321	.037	.010	3	1
UCEC	PDCD4 →	-0.672	-2.312	.001	.034	3	1
UCEC	STAT3_pY705 →	-0.414	-2.000	<.001	.032	3	1
UCEC	AR →	-0.468	-3.321	.005	.010	3	1
UCEC	TFRC →	+0.504	+3.000	.035	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p62 Lck ligand by C3orf52 expression — UCEC

Explore this box plot interactively →