C3orf52

Across TCGA patient cohorts, C3orf52 mutation is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible C3orf52-associated genes across cancer lineages are MIR6765, MIR378E, and IGHD5-24. Each is linked with C3orf52 in more than 1 cancer types. Because this analysis shows association rather than direction, both C3orf52-to-partner and partner-to-C3orf52 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6765 grouped by C3orf52-low versus C3orf52-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (C3orf52→partner) and Y-score (partner→C3orf52) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR6765 →	+0.418	+5.201	<.001	.007	3	2
UCEC	MIR378E →	+0.243	+3.132	<.001	.005	3	2
CESC	IGHD5-24 →	+1.758	+5.669	<.001	.003	3	2
SCLC	ACTL9 →	+0.156	+4.847	<.001	.009	3	1
CESC	RN7SL62P →	+0.213	+5.812	<.001	.003	3	1
CESC	RN7SL97P →	+0.211	+6.144	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

MIR6765 by C3orf52 expression — CESC

Explore this box plot interactively →