bone morphogenetic protein receptor type 1BGenealiases: ALK-6 · ALK6 · AMD3 · AMDD · BDA1D · BDA2
Q-omics provides the consensus-scored BMPR1B profile across patient tissues and cancer cell-line models. BMPR1B expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, BMPR1B is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, BMPR1B RNA expression shows 17,434 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRP, KIRC, and UVM as cancer lineages where BMPR1B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BMPR1B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BMPR1B survival associations across molecular data types. BMPR1B RNA expression shows survival associations in the most cancer types (22), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BMPR1B RNA expression–survival associations across cancer types. High BMPR1B expression shows unfavorable associations in KIRP, UVM, LUAD and THCA, but favorable associations in UCEC and ACC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for BMPR1B RNA expression.
This table summarizes BMPR1B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for BMPR1B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BMPR1B shows lower tumor expression in KIRC, THCA, KIRP and STAD and higher tumor expression in HNSC and BRCA. The KIRC box plot shows higher BMPR1B RNA expression in normal versus tumor tissue (log2 FC = −3.515, t-test p < 0.001).
This table shows molecular features associated with BMPR1B in patient tissues and cancer cell lines. In patient samples, BMPR1B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, BMPR1B RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in LIVER and SKIN.
