BMPR1B

Across TCGA patient cohorts, BMPR1B mutation is significantly associated with the RNA expression of many other genes, with 1,267 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMPR1B-associated genes across cancer lineages are UQCRHP3, VN1R66P, and WRN. Each is linked with BMPR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both BMPR1B-to-partner and partner-to-BMPR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRHP3 grouped by BMPR1B-low versus BMPR1B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR1B→partner) and Y-score (partner→BMPR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	UQCRHP3 →	+0.176	+4.211	<.001	.003	3	2
BRCA	VN1R66P →	+0.042	+4.527	<.001	.007	3	2
UCEC	WRN →	+0.708	+3.475	<.001	.002	3	2
UCEC	DHODH →	+0.390	+3.711	.005	<.001	3	2
UCEC	TTI2 →	+0.689	+3.711	<.001	<.001	3	2
UCEC	ZIC5 →	+1.533	+2.530	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,267 associations by consensus.

UQCRHP3 by BMPR1B expression — BRCA

Explore this box plot interactively →