BMPR1B

Across TCGA cell cohorts, BMPR1B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BMPR1B-associated genes across cancer lineages are GYS2, SLC10A2, and DMRTC2. Each is linked with BMPR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both BMPR1B-to-partner and partner-to-BMPR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYS2 grouped by BMPR1B-low versus BMPR1B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR1B→partner) and Y-score (partner→BMPR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GYS2 →	+0.010	+4.467	.003	.004	3	1
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
SKIN	DMRTC2 →	+0.053	+4.415	<.001	.007	3	1
SKIN	OR52I2 →	+0.010	+4.095	.001	.009	3	1
LARGE_INTESTINE	IAPP →	+0.453	+3.906	<.001	.005	3	1
LARGE_INTESTINE	MYO3A →	+0.729	+3.491	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GYS2 by BMPR1B expression — SKIN

Explore this box plot interactively →