BMPR1B

Across TCGA patient cohorts, BMPR1B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMPR1B-associated genes across cancer lineages are CD49b, EGFR_pY1068, and A-Raf_pS299. Each is linked with BMPR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both BMPR1B-to-partner and partner-to-BMPR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by BMPR1B-low versus BMPR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMPR1B→partner) and Y-score (partner→BMPR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD49b →	-0.372	-2.308	.009	.036	3	2
UCEC	EGFR_pY1068 →	-0.314	-3.459	.012	.005	3	1
UCEC	A-Raf_pS299 →	-0.199	-3.169	<.001	.019	3	1
UCEC	INPP4B →	-0.386	-2.999	.017	.035	3	1
UCEC	JNK2 →	+0.282	+2.321	.004	.035	3	1
UCEC	Ku80 →	+0.322	+3.472	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

CD49b by BMPR1B expression — UCEC

Explore this box plot interactively →