biogenesis of lysosomal organelles complex 1 subunit 5Genealiases: BLOS5 · HPS11 · MU · MUTED
Q-omics provides the consensus-scored BLOC1S5 profile across patient tissues and cancer cell-line models. BLOC1S5 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, BLOC1S5 is differentially expressed in 12, with the highest sampling consensus in KICH. Additionally, BLOC1S5 RNA expression shows 19,342 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, KICH, and ACC as cancer lineages where BLOC1S5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BLOC1S5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BLOC1S5 survival associations across molecular data types. BLOC1S5 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (2) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BLOC1S5 RNA expression–survival associations across cancer types. High BLOC1S5 expression shows unfavorable associations in LIHC and MESO, but favorable associations in KIRC, READ, LUAD and UCS. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for BLOC1S5 RNA expression.
This table summarizes BLOC1S5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for BLOC1S5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BLOC1S5 shows lower tumor expression in KICH and THCA and higher tumor expression in LIHC, LUAD, HNSC and BLCA. The KICH box plot shows higher BLOC1S5 RNA expression in normal versus tumor tissue (log2 FC = −2.732, t-test p < 0.001).
This table shows molecular features associated with BLOC1S5 in patient tissues and cancer cell lines. In patient samples, BLOC1S5 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, BLOC1S5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
