Across TCGA patient cohorts, BLOC1S5 mutation is significantly associated with the RNA expression of many other genes, with 368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLOC1S5-associated genes across cancer lineages are EIF3JP1, YTHDF3-AS1, and MIR7702. Each is linked with BLOC1S5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S5-to-partner and partner-to-BLOC1S5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S5→partner) and Y-score (partner→BLOC1S5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EIF3JP1 →	+0.156	+2.257	.005	.009	3	2
UCEC	YTHDF3-AS1 →	+0.805	+3.354	<.001	.005	3	1
UCEC	MIR7702 →	+0.263	+4.475	<.001	.003	3	1
UCEC	H3C1 →	+1.219	+3.711	<.001	<.001	3	1
UCEC	GTSE1-DT →	+0.825	+3.364	<.001	.004	3	1
UCEC	H2AC4 →	+0.571	+2.595	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

Exploration

BLOC1S5 survival (RNA) · tumor vs normal (RNA) · all BLOC1S5 data types