Across TCGA patient cohorts, BLOC1S5 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLOC1S5-associated genes across cancer lineages are p62 Lck ligand, Tuberin, and Caspase-8. Each is linked with BLOC1S5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S5-to-partner and partner-to-BLOC1S5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S5→partner) and Y-score (partner→BLOC1S5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.372	+2.817	.029	.036	3	1
UCEC	Tuberin →	+0.362	+3.321	.010	.010	3	1
UCEC	Caspase-8 →	-0.324	-3.321	.014	.010	2	1
UCEC	S6_pS240_S244 →	+0.545	+3.321	.010	.010	1	1
UCEC	14-3-3_zeta →	-0.232	-3.295	.031	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

BLOC1S5 survival (RNA) · tumor vs normal (RNA) · all BLOC1S5 data types