Across TCGA pan-cancer cohorts, BLOC1S5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BLOC1S5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where BLOC1S5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BLOC1S5 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, CCRCC, and PDAC are the cancer types where BLOC1S5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLOC1S5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.413	<.001	9	view →
CCRCC	Male	III,IV	+0.341	<.001	9	view →
PDAC	All	III,IV	−0.786	<.001	8	view →
LSCC	Male	All	+0.132	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: BLOC1S5 RNA expression & survival · all BLOC1S5 data types