adaptor related protein complex 4 subunit mu 1Genealiases: CPSQ3 · MU-4 · MU-ARP2 · SPG50
Q-omics provides the consensus-scored AP4M1 profile across patient tissues and cancer cell-line models. AP4M1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, AP4M1 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, AP4M1 RNA expression shows 18,639 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KICH, KIRC, and ACC as cancer lineages where AP4M1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for AP4M1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes AP4M1 survival associations across molecular data types. AP4M1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible AP4M1 RNA expression–survival associations across cancer types. High AP4M1 expression shows unfavorable associations in KICH, LIHC, LGG, MESO and STAD, but favorable associations in CHOL. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for AP4M1 RNA expression.
This table summarizes AP4M1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for AP4M1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. AP4M1 shows higher tumor expression in KIRC, HNSC, COAD, LUAD, LIHC and KIRP. The KIRC box plot shows higher AP4M1 RNA expression in tumor versus normal tissue (log2 FC = +0.853, t-test p < 0.001).
This table shows molecular features associated with AP4M1 in patient tissues and cancer cell lines. In patient samples, AP4M1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, AP4M1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
