Across TCGA cell cohorts, AP4M1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AP4M1-associated genes across cancer lineages are MTRNR2L6, TFAP2D, and MAP1LC3C. Each is linked with AP4M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4M1-to-partner and partner-to-AP4M1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4M1→partner) and Y-score (partner→AP4M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
BLOOD_Leukemia	MAP1LC3C →	+0.030	+2.948	.003	.008	3	1
BLOOD_Leukemia	AKR1B15 →	+0.023	+3.606	<.001	.002	3	1
BLOOD_Leukemia	DCX →	+0.022	+3.607	<.001	.004	3	1
LARGE_INTESTINE	SIRPD →	+0.025	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

AP4M1 survival (RNA) · tumor vs normal (RNA) · all AP4M1 data types