Across TCGA patient cohorts, AP4M1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AP4M1-associated genes across cancer lineages are Shc_pY317, 14-3-3_beta, and EGFR_pY1068. Each is linked with AP4M1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AP4M1-to-partner and partner-to-AP4M1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AP4M1→partner) and Y-score (partner→AP4M1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.179	-2.459	.009	.019	3	2
UCEC	14-3-3_beta →	-0.126	-3.295	.005	.009	3	1
UCEC	EGFR_pY1068 →	-0.263	-3.169	.020	.019	3	1
UCEC	ERK2 →	+0.247	+2.000	.004	.032	3	1
UCEC	Heregulin →	-0.155	-2.321	.005	.034	3	1
UCEC	JNK2 →	+0.279	+2.179	.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

AP4M1 survival (RNA) · tumor vs normal (RNA) · all AP4M1 data types