Q-omics provides the consensus-scored ANKRD27 profile across patient tissues and cancer cell-line models. ANKRD27 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ANKRD27 is differentially expressed in 11, with the highest sampling consensus in HNSC. Additionally, ANKRD27 RNA expression shows 20,507 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight ACC, and HNSC as cancer lineages where ANKRD27 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ANKRD27 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ANKRD27 survival associations across molecular data types. ANKRD27 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (5) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ANKRD27 RNA expression–survival associations across cancer types. High ANKRD27 expression shows unfavorable associations in ACC, LIHC, CESC, OV and LGG, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ANKRD27 RNA expression.
This table summarizes ANKRD27 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in HNSC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for ANKRD27. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ANKRD27 shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, COAD, BRCA and CHOL. The HNSC box plot shows higher ANKRD27 RNA expression in tumor versus normal tissue (log2 FC = +0.797, t-test p < 0.001).
This table shows molecular features associated with ANKRD27 in patient tissues and cancer cell lines. In patient samples, ANKRD27 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, ANKRD27 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and BLOOD_Leukemia.
