ANKRD27

Across TCGA patient cohorts, ANKRD27 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ANKRD27-associated genes across cancer lineages are p53, p62 Lck ligand, and ASNS. Each is linked with ANKRD27 in more than 2 cancer types. Because this analysis shows association rather than direction, both ANKRD27-to-partner and partner-to-ANKRD27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by ANKRD27-low versus ANKRD27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ANKRD27→partner) and Y-score (partner→ANKRD27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.266	-1.807	.012	.024	3	3
UCEC	p62 Lck ligand →	+0.307	+1.917	<.001	<.001	3	3
UCEC	ASNS →	+0.287	+1.263	.003	.016	3	3
COAD	MEK1 →	+0.335	+3.017	.001	.017	3	2
COAD	ATM →	-0.623	-2.991	.002	.036	3	2
COAD	Claudin-7 →	+0.725	+3.008	.035	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p53 by ANKRD27 expression — UCEC

Explore this box plot interactively →