ANKRD27

Across TCGA pan-cancer cohorts, ANKRD27 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANKRD27 data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ANKRD27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ANKRD27 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UVM, UCEC, and KICH are the cancer types where ANKRD27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.213	0.718	.002	27	view →
UCEC	DFS	Median	All	0.962	0.620	.002	20	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
ESCA	OS	Median	II,III,IV	0.321	0.685	.035	6	view →
SKCM	OS	Median	III,IV	0.245	0.721	.018	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANKRD27–UVM (OS)

Open the UVM breakdown →