ANKRD27

Across TCGA pan-cancer cohorts, ANKRD27 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ANKRD27 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher ANKRD27 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ANKRD27 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

GBM, PDAC, and UCEC are the cancer types where ANKRD27 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.214	0.442	.006	10	view →
PDAC	OS	Tertile	All	0.972	0.748	.011	5	view →
UCEC	DFS	Tertile	All	0.811	0.963	.023	4	view →
LSCC	DFS	Tertile	II,III,IV	0.330	1.000	.006	4	view →
HNSC	OS	Quartile	IV	1.000	0.829	.022	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ANKRD27–GBM (DFS)

Open the GBM breakdown →