aldehyde dehydrogenase 1 family member B1Genealiases: ALDH5 · ALDHX
Q-omics provides the consensus-scored ALDH1B1 profile across patient tissues and cancer cell-line models. ALDH1B1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, ALDH1B1 is differentially expressed in 15, with the highest sampling consensus in LUAD. Additionally, ALDH1B1 protein abundance shows 22,530 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight ACC, LUAD, and HNSC as cancer lineages where ALDH1B1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ALDH1B1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ALDH1B1 survival associations across molecular data types. ALDH1B1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (6) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ALDH1B1 RNA expression–survival associations across cancer types. High ALDH1B1 expression shows unfavorable associations in ACC, MESO, CESC, CHOL and HNSC, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for ALDH1B1 RNA expression.
This table summarizes ALDH1B1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 7. The strongest signals are observed in LUAD for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for ALDH1B1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ALDH1B1 shows lower tumor expression in THCA, KICH, BLCA and KIRC and higher tumor expression in LUAD and COAD. The LUAD box plot shows higher ALDH1B1 RNA expression in tumor versus normal tissue (log2 FC = +1.843, t-test p < 0.001).
This table shows molecular features associated with ALDH1B1 in patient tissues and cancer cell lines. In patient samples, ALDH1B1 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, ALDH1B1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in LIVER and PANCREAS.
