ALDH1B1

Across TCGA patient cohorts, ALDH1B1 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ALDH1B1-associated genes across cancer lineages are C-Raf, eIF4E, and FASN. Each is linked with ALDH1B1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ALDH1B1-to-partner and partner-to-ALDH1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ALDH1B1-low versus ALDH1B1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1B1→partner) and Y-score (partner→ALDH1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.178	+2.584	<.001	.010	3	3
UCEC	eIF4E →	+0.178	+3.000	.017	<.001	3	2
UCEC	FASN →	+0.274	+2.321	.049	.033	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.483	+2.424	.007	.001	3	2
UCEC	INPP4B →	-0.243	-2.000	.033	.029	3	2
UCEC	Ku80 →	+0.292	+1.857	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

C-Raf by ALDH1B1 expression — UCEC

Explore this box plot interactively →