ALDH1B1

Across TCGA cell cohorts, ALDH1B1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,736 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible ALDH1B1-associated GO terms across cancer lineages are Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with ALDH1B1 in more than 9 cancer types. Because this analysis shows association rather than direction, both ALDH1B1-to-partner and partner-to-ALDH1B1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by ALDH1B1-low versus ALDH1B1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ALDH1B1→partner) and Y-score (partner→ALDH1B1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.139	+1.191	<.001	.001	3	10
SOFT_TISSUE	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.106	+1.212	<.001	.002	3	10
URINARY_TRACT	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.143	+1.048	<.001	.003	3	10
URINARY_TRACT	Transcription elongation by RNA polymerase I →	+0.118	+1.013	.002	.006	3	10
PANCREAS	Termination of RNA polymerase I transcription →	+0.103	+0.999	<.001	<.001	3	10
PANCREAS	rRNA transcription →	+0.085	+0.803	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,736 associations by consensus.

Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by ALDH1B1 expression — URINARY_TRACT

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