ALDH1B1

Across TCGA pan-cancer cohorts, ALDH1B1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ALDH1B1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ALDH1B1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ALDH1B1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where ALDH1B1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.564	0.841	<.001	42	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	15	view →
CCRCC	OS	Tertile	All	1.000	0.878	.010	14	view →
LUAD	DFS	Quartile	All	1.000	0.792	.005	8	view →
GBM	OS	Median	All	0.447	0.306	.019	4	view →
HNSC	DFS	Median	III,IV	0.882	0.724	.015	3	view →
UCEC	OS	Tertile	All	0.868	1.000	.020	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ALDH1B1–LSCC (DFS)

Open the LSCC breakdown →