"Response to 2,3,7,8-tetrachlorodibenzodioxine"

Across TCGA patient cohorts, RNA activity of the "Response to 2,3,7,8-tetrachlorodibenzodioxine" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR12, FCHO2, and RFC4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Response to 2,3,7,8-tetrachlorodibenzodioxine" activity versus WDR12 in LSCC (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR12 →	-0.399	-0.099	<.001	<.001	3	8
OV	FCHO2 →	+0.248	+0.066	.009	.005	3	7
LSCC	RFC4 →	-0.377	-0.085	.001	<.001	3	6
GBM	SNRNP40 →	-0.219	-0.087	.001	.001	3	6
GBM	SSRP1_S444 →	-0.487	-0.109	<.001	<.001	3	6
GBM	SUPT16H →	-0.565	-0.106	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904612 vs WDR12 — LSCC

Explore this scatter interactively →