GO:1904612Ontology (GO BP)GO biological process · ~5 member genes
Q-omics provides the "Response to 2,3,7,8-tetrachlorodibenzodioxine" (GO:1904612) pathway profile, scoring each patient from the combined activity of its roughly 5 member genes. Pathway activity is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 15, with the highest sampling consensus in KICH. Additionally, pathway RNA activity shows 32,414 significant cross-omics associations, again with the highest sampling consensus in BRCA. Together, these results highlight KIRC, KICH, and BRCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes "Response to 2,3,7,8-tetrachlorodibenzodioxine" survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High "Response to 2,3,7,8-tetrachlorodibenzodioxine" activity shows favorable associations in KIRC, LIHC and KIRP, but unfavorable associations in HNSC, UVM and THYM. In the KIRC Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). KIRC ranks highest by sampling consensus for "Response to 2,3,7,8-tetrachlorodibenzodioxine".
This table summarizes "Response to 2,3,7,8-tetrachlorodibenzodioxine" tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 15 cancer types, while mass-spec protein activity shows differences in 5. The strongest signals are in KIRP for RNA and LUAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows consistently lower tumor activity across KICH, KIRP, THCA, BLCA, COAD and LUSC. In the KICH box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.156, t-test p < 0.001).
This table shows molecular features associated with "Response to 2,3,7,8-tetrachlorodibenzodioxine" pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in BRCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in SOFT_TISSUE.
