"Response to 2,3,7,8-tetrachlorodibenzodioxine"

Across TCGA cell cohorts, RNA activity of the "Response to 2,3,7,8-tetrachlorodibenzodioxine" pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBLB, IFT80, and SERPINA12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBLB grouped by "Response to 2,3,7,8-tetrachlorodibenzodioxine"-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	CBLB →	-0.321	-0.340	<.001	.002	2	5
LARGE_INTESTINE	IFT80 →	-0.161	-0.685	.003	.006	3	4
OVARY	SERPINA12 →	-0.394	-1.193	<.001	.001	3	3
OVARY	ZNF620 →	+0.164	+0.885	<.001	.005	3	3
BLOOD_Myeloma	CACNB4 →	-0.282	-1.302	.002	.005	3	3
OVARY	CELSR1 →	-0.213	-0.848	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBLB by "Response to 2,3,7,8-tetrachlorodibenzodioxine" activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →