"Response to 2,3,7,8-tetrachlorodibenzodioxine"

Across TCGA patient cohorts, RNA activity of the "Response to 2,3,7,8-tetrachlorodibenzodioxine" pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S1PR5, PDE2A, and ADCY4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Response to 2,3,7,8-tetrachlorodibenzodioxine" activity versus S1PR5 in CCRCC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	S1PR5 →	+0.954	+0.563	<.001	<.001	3	4
CCRCC	PDE2A →	+1.098	+0.560	<.001	<.001	3	4
CCRCC	ADCY4 →	+1.133	+0.658	<.001	<.001	3	3
CCRCC	DIPK2B →	+1.245	+0.580	<.001	<.001	3	3
LSCC	CLIC5 →	+1.002	+0.238	<.001	.005	3	3
CCRCC	RHOU →	+0.612	+0.448	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904612 vs S1PR5 — CCRCC

Explore this scatter interactively →