Response to glycoprotein

Across TCGA patient cohorts, RNA activity of the Response to glycoprotein pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGA3, MAN1B1, and NIBAN2_S696, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to glycoprotein activity versus ITGA3 in GBM (Pearson r = 0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITGA3 →	+0.842	+0.193	<.001	<.001	3	6
PDAC	MAN1B1 →	+0.372	+0.050	<.001	<.001	3	6
GBM	NIBAN2_S696 →	+0.573	+0.155	<.001	<.001	3	6
LSCC	FHOD1_S523 →	+0.462	+0.069	<.001	<.001	3	6
OV	USP25 →	+0.169	+0.059	.002	<.001	3	6
GBM	RIPK1 →	+0.276	+0.136	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904587 vs ITGA3 — GBM

Explore this scatter interactively →