Positive regulation of voltage-gated potassium channel activity
associated omics data
GO:1903818Ontology (GO BP)GO biological process · ~12 member genes
Q-omics provides the Positive regulation of voltage-gated potassium channel activity (GO:1903818) pathway profile, scoring each patient from the combined activity of its roughly 12 member genes. Pathway activity is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in PAAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 9, with the highest sampling consensus in KICH. Additionally, pathway RNA activity shows 27,643 significant cross-omics associations, again with the highest sampling consensus in BRCA. Together, these results highlight PAAD, KICH, and BRCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Positive regulation of voltage-gated potassium channel activity survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Positive regulation of voltage-gated potassium channel activity activity shows favorable associations in PAAD, STAD, LUSC and KIRP, but unfavorable associations in PRAD and COAD. In the PAAD Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). PAAD ranks highest by sampling consensus for Positive regulation of voltage-gated potassium channel activity.
This table summarizes Positive regulation of voltage-gated potassium channel activity tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 9 cancer types, while mass-spec protein activity shows differences in 2. The strongest signals are in STAD for RNA and PDAC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across KICH, KIRP, STAD and KIRC and lower tumor activity in COAD and BRCA. In the KICH box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.058, t-test p < 0.001).
This table shows molecular features associated with Positive regulation of voltage-gated potassium channel activity pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in BRCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in PANCREAS.
