Positive regulation of voltage-gated potassium channel activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of voltage-gated potassium channel activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF2, SFXN1, and C1orf226_S223, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of voltage-gated potassium channel activity activity versus WIPF2 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WIPF2 →	+0.231	+0.036	.004	<.001	3	5
CCRCC	SFXN1 →	+0.264	+0.061	.002	.001	3	4
BRCA	C1orf226_S223 →	+0.751	+0.057	.001	<.001	3	4
LSCC	PRG2 →	-0.677	-0.049	<.001	<.001	3	4
LUAD	PDGFRB →	-0.203	-0.047	.002	.006	3	4
LUAD	PMVK →	+0.288	+0.056	.009	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1903818 vs WIPF2 — BRCA

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