Positive regulation of voltage-gated potassium channel activity

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of voltage-gated potassium channel activity pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher Positive regulation of voltage-gated potassium channel activity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and STAD, show the opposite pattern, with higher activity associated with better survival.

PAAD, STAD, and PRAD are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.731	0.488	<.001	61	view →
STAD	DFS	Tertile	All	0.627	0.489	.021	27	view →
PRAD	DFS	Median	All	0.690	0.867	<.001	22	view →
LUSC	OS	Median	II,III,IV	0.806	0.670	.009	22	view →
KIRP	OS	Quartile	III,IV	0.710	0.291	.018	21	view →
COAD	OS	Tertile	III,IV	0.686	0.917	.002	17	view →
UCS	OS	Tertile	II,III,IV	0.578	0.241	.031	16	view →
KICH	DFS	Quartile	II,III,IV	0.464	0.942	.001	16	view →
LGG	OS	Median	All	0.927	0.842	.002	14	view →
SCLC	DFS	Quartile	III,IV	0.656	0.332	.019	10	view →
GBM	DFS	Tertile	All	0.293	0.152	.002	9	view →
ACC	DFS	Quartile	All	0.296	0.808	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:1903818–PAAD (OS)

Open the PAAD breakdown →