Positive regulation of voltage-gated potassium channel activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of voltage-gated potassium channel activity pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEDD4L, PELI3, and CERS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NEDD4L grouped by Positive regulation of voltage-gated potassium channel activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NEDD4L →	+1.352	+0.999	<.001	.004	3	4
BLOOD_Leukemia	PELI3 →	-2.035	-1.456	<.001	.001	3	4
SKIN	CERS1 →	+1.175	+0.957	.001	<.001	3	3
LUNG_NSCLC_LUAD	TTC19 →	+0.703	+0.936	.005	.004	3	3
LIVER	NQO2 →	-1.667	-1.343	.002	.002	2	4
LUNG_NSCLC_LUAD	CASP1 →	-1.504	-1.075	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NEDD4L by Positive regulation of voltage-gated potassium channel activity activity — KIDNEY

Explore this box plot interactively →