Positive regulation of voltage-gated potassium channel activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of voltage-gated potassium channel activity pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL3, CDK2AP2, and PRKCZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCHL3 grouped by Positive regulation of voltage-gated potassium channel activity-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	UCHL3 →	+0.205	+0.194	.002	.003	2	5
OVARY	CDK2AP2 →	+0.289	+0.172	.001	.005	2	5
BREAST	PRKCZ →	+0.213	+1.224	<.001	<.001	3	4
BONE	KCNJ14 →	+0.262	+0.214	.005	.009	3	4
BLOOD_Leukemia	PRKAB2 →	+0.224	+1.331	<.001	.003	3	4
BLOOD_Lymphoma	MED12 →	+0.449	+0.303	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCHL3 by Positive regulation of voltage-gated potassium channel activity activity — KIDNEY

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