De novo centriole assembly involved in multi-ciliated epithelial cell differentiation

Across TCGA patient cohorts, RNA activity of the De novo centriole assembly involved in multi-ciliated epithelial cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are POLD1, RFC2, and SETDB1_S1066, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, De novo centriole assembly involved in multi-ciliated epithelial cell differentiation activity versus POLD1 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	POLD1 →	+0.307	+0.109	<.001	<.001	3	8
GBM	RFC2 →	+0.339	+0.096	<.001	<.001	3	7
GBM	SETDB1_S1066 →	+0.894	+0.130	<.001	<.001	3	7
GBM	SMC4 →	+0.626	+0.126	<.001	<.001	3	7
LUAD	CDK1 →	+0.933	+0.091	<.001	<.001	3	7
CCRCC	KIF11_T926 →	+0.859	+0.070	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0098535 vs POLD1 — GBM

Explore this scatter interactively →