De novo centriole assembly involved in multi-ciliated epithelial cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the De novo centriole assembly involved in multi-ciliated epithelial cell differentiation pathway differs between tumor and matched normal tissue in 14 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is higher in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors.

KICH, KIRP, and BLCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	All	IV	+0.155	<.001	11	view →
KIRP	All	II,III,IV	+0.127	<.001	11	view →
BLCA	Male	All	+0.107	<.001	11	view →
KIRC	Male	All	+0.070	<.001	11	view →
COAD	All	II,III,IV	+0.056	<.001	9	view →
STAD	All	II,III,IV	+0.094	<.001	8	view →
LIHC	Male	All	+0.064	<.001	8	view →
LUSC	All	II,III,IV	+0.057	<.001	7	view →
UCEC	All	All	+0.071	<.001	6	view →
BRCA	All	II,III,IV	+0.069	<.001	6	view →
ESCA	All	All	+0.123	.003	4	view →
CHOL	Male	All	+0.150	<.001	3	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 14 lineages.

GO:0098535–KICH

Open the KICH breakdown →