GO:0097709Ontology (GO BP)GO biological process · ~17 member genes
Q-omics provides the Connective tissue replacement (GO:0097709) pathway profile, scoring each patient from the combined activity of its roughly 17 member genes. Pathway activity is associated with patient survival in 18 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 11, with the highest sampling consensus in HNSC. Additionally, pathway RNA activity shows 35,604 significant cross-omics associations, again with the highest sampling consensus in BRCA. Together, these results highlight SKCM, HNSC, and BRCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Connective tissue replacement survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (18). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Connective tissue replacement activity shows favorable associations in SKCM and ESCA, but unfavorable associations in KIRP, MESO, CESC and THCA. In the SKCM Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). SKCM ranks highest by sampling consensus for Connective tissue replacement.
This table summarizes Connective tissue replacement tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 11 cancer types, while mass-spec protein activity shows differences in 4. The strongest signals are in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across HNSC and STAD and lower tumor activity in KICH, KIRP, BRCA and KIRC. In the HNSC box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.106, t-test p < 0.001).
This table shows molecular features associated with Connective tissue replacement pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in BRCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in URINARY_TRACT.
