Connective tissue replacement

Across TCGA patient cohorts, RNA activity of the Connective tissue replacement pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR68, TPM2, and MSRB3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Connective tissue replacement activity versus GPR68 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GPR68 →	+0.579	+0.284	<.001	.004	3	4
OV	TPM2 →	+1.096	+0.366	<.001	.005	3	4
OV	MSRB3 →	+1.328	+0.451	<.001	<.001	3	4
COAD	INMT →	+0.477	+0.684	.004	.004	3	4
OV	IFFO1 →	+0.701	+0.371	.001	.008	3	3
BRCA	BATF3 →	+0.557	+0.363	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097709 vs GPR68 — BRCA

Explore this scatter interactively →