Connective tissue replacement

Across TCGA cell cohorts, RNA activity of the Connective tissue replacement pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are P2RY11, ZGLP1, and IRF5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, P2RY11 grouped by Connective tissue replacement-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	P2RY11 →	+1.180	+0.962	<.001	.001	3	6
CNS	ZGLP1 →	+0.529	+0.729	.004	.009	3	4
OVARY	IRF5 →	+1.691	+1.250	.004	.001	3	4
CNS	RPL22 →	-0.659	-0.895	<.001	.003	3	3
LARGE_INTESTINE	H4C8 →	+0.987	+0.946	.004	.006	2	4
CNS	RPL8 →	-0.564	-0.995	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

P2RY11 by Connective tissue replacement activity — PANCREAS

Explore this box plot interactively →