Connective tissue replacement

Across TCGA patient cohorts, RNA activity of the Connective tissue replacement pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VIM, APCS, and TANGO2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Connective tissue replacement activity versus VIM in PDAC (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VIM →	+0.551	+0.066	<.001	<.001	3	9
GBM	APCS →	+0.875	+0.069	<.001	.001	3	9
LSCC	TANGO2 →	+0.326	+0.099	<.001	<.001	3	9
LSCC	STRBP →	-0.705	-0.142	<.001	<.001	3	8
GBM	BGN →	+1.004	+0.097	<.001	<.001	3	8
OV	COMP →	+1.376	+0.122	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097709 vs VIM — PDAC

Explore this scatter interactively →