transport and golgi organization 2 homologGenealiases: C22orf25 · MECRCN
Q-omics provides the consensus-scored TANGO2 profile across patient tissues and cancer cell-line models. TANGO2 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, TANGO2 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, TANGO2 protein abundance shows 29,312 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRP, HNSC, and LSCC as cancer lineages where TANGO2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TANGO2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TANGO2 survival associations across molecular data types. TANGO2 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (3) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TANGO2 RNA expression–survival associations across cancer types. High TANGO2 expression shows unfavorable associations in KIRC and LIHC, but favorable associations in KIRP, SCLC, LUAD and CESC. The KIRP Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .002). Together, the overview and detailed table identify KIRP as the clearest survival context for TANGO2 RNA expression.
This table summarizes TANGO2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for TANGO2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TANGO2 shows lower tumor expression in LUAD, THCA and LUSC and higher tumor expression in HNSC, KICH and LIHC. The HNSC box plot shows higher TANGO2 RNA expression in tumor versus normal tissue (log2 FC = +0.976, t-test p < 0.001).
This table shows molecular features associated with TANGO2 in patient tissues and cancer cell lines. In patient samples, TANGO2 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, TANGO2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
