Across TCGA cell cohorts, TANGO2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TANGO2-associated genes across cancer lineages are MAGEB4, STRA8, and G6PC2. Each is linked with TANGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TANGO2-to-partner and partner-to-TANGO2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TANGO2→partner) and Y-score (partner→TANGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	STRA8 →	+0.118	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	G6PC2 →	+0.027	+3.658	.006	.005	3	1
LARGE_INTESTINE	PRR27 →	+0.174	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	COL25A1 →	+0.042	+4.070	.007	.003	3	1
LARGE_INTESTINE	C16orf96 →	+0.707	+4.237	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

TANGO2 survival (RNA) · tumor vs normal (RNA) · all TANGO2 data types