Ubiquitin-dependent glycoprotein ERAD pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent glycoprotein ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN1A1, LYSMD3, and MAN2A1, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent glycoprotein ERAD pathway activity versus MAN1A1 in DLBC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	MAN1A1 →	+1.911	+0.083	<.001	<.001	3	34
UVM	LYSMD3 →	+1.163	+0.071	<.001	<.001	3	34
KICH	MAN2A1 →	+1.280	+0.064	<.001	<.001	3	33
THYM	TGFBR2 →	+1.399	+0.086	<.001	<.001	3	33
DLBC	MAN1A2 →	+1.273	+0.073	<.001	<.001	3	33
DLBC	SEC24A →	+1.071	+0.068	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097466 vs MAN1A1 — DLBC

Explore this scatter interactively →