Ubiquitin-dependent glycoprotein ERAD pathway

Across TCGA patient cohorts, RNA activity of the Ubiquitin-dependent glycoprotein ERAD pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAN1B1, KLHL7, and RNASEL, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ubiquitin-dependent glycoprotein ERAD pathway activity versus MAN1B1 in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MAN1B1 →	+0.472	+0.058	<.001	<.001	3	6
BRCA	KLHL7 →	-0.258	-0.063	.001	<.001	3	5
OV	RNASEL →	+0.308	+0.068	.005	.001	3	5
OV	FAP →	+0.840	+0.056	<.001	<.001	3	5
OV	FBLN2 →	+0.934	+0.060	.001	.001	3	5
OV	FBXW2 →	+0.367	+0.061	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0097466 vs MAN1B1 — PDAC

Explore this scatter interactively →