Ubiquitin-dependent glycoprotein ERAD pathway

Across TCGA cell cohorts, RNA activity of the Ubiquitin-dependent glycoprotein ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAIP2B, SAMD12, and SPAG4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PAIP2B grouped by Ubiquitin-dependent glycoprotein ERAD pathway-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PAIP2B →	+1.336	+1.474	.001	.004	3	4
SKIN	SAMD12 →	+0.984	+1.063	.002	.001	3	4
BONE	SPAG4 →	-0.770	-2.118	.007	.007	3	4
SKIN	TMCC2 →	-1.182	-1.246	.009	.002	3	3
LUNG_NSCLC_LUSC	DSG2 →	+2.872	+1.910	.003	<.001	3	3
SKIN	ST3GAL6 →	-2.158	-1.220	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PAIP2B by Ubiquitin-dependent glycoprotein ERAD pathway activity — STOMACH

Explore this box plot interactively →