Positive regulation of transforming growth factor beta production

Across TCGA patient cohorts, RNA activity of the Positive regulation of transforming growth factor beta production pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STUB1_S19, ZNF318_S464, and RAB29, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of transforming growth factor beta production activity versus STUB1_S19 in OV (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STUB1_S19 →	-0.569	-0.038	.006	.001	3	5
OV	ZNF318_S464 →	-0.520	-0.027	.004	.004	3	5
OV	RAB29 →	+0.311	+0.028	.003	.005	3	5
HNSC	DOCK4_T1899 →	+0.340	+0.066	.003	.001	3	5
HNSC	G3BP1 →	-0.120	-0.046	.002	.001	3	5
GBM	HAAO →	+0.500	+0.099	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071636 vs STUB1_S19 — OV

Explore this scatter interactively →