Positive regulation of transforming growth factor beta production

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of transforming growth factor beta production pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and BLCA, show the opposite pattern, with lower activity in tumor tissue.

KICH, BLCA, and COAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Female	All	−0.072	<.001	9	view →
BLCA	Male	All	−0.086	<.001	8	view →
COAD	All	All	+0.033	<.001	8	view →
KIRC	Male	All	+0.023	<.001	8	view →
UCEC	All	III,IV	−0.103	<.001	6	view →
BRCA	All	III,IV	−0.063	<.001	6	view →
HNSC	Female	All	+0.035	.008	6	view →
STAD	All	All	+0.066	<.001	4	view →
LUSC	Female	All	−0.047	.001	4	view →
CHOL	All	All	+0.047	.031	3	view →
PAAD	Female	All	+0.104	.002	2	view →
KIRP	All	IV	+0.050	.008	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0071636–KICH

Open the KICH breakdown →