GO:0071377Ontology (GO BP)GO biological process · ~12 member genes
Q-omics provides the Cellular response to glucagon stimulus (GO:0071377) pathway profile, scoring each patient from the combined activity of its roughly 12 member genes. Pathway activity is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in STAD. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 13, with the highest sampling consensus in LUSC. Additionally, pathway RNA activity shows 29,323 significant cross-omics associations, again with the highest sampling consensus in LIHC. Together, these results highlight STAD, LUSC, and LIHC as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Cellular response to glucagon stimulus survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (24). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Cellular response to glucagon stimulus activity shows favorable associations in STAD, LIHC and ACC, but unfavorable associations in UVM, SKCM and BRCA. In the STAD Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). STAD ranks highest by sampling consensus for Cellular response to glucagon stimulus.
This table summarizes Cellular response to glucagon stimulus tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 13 cancer types, while mass-spec protein activity shows differences in 4. The strongest signals are in LUSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across LUSC, LUAD and BRCA and lower tumor activity in LIHC, COAD and KIRP. In the LUSC box plot, tumor samples show higher pathway activity than matched normal samples (log2 FC = +0.211, t-test p < 0.001).
This table shows molecular features associated with Cellular response to glucagon stimulus pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in LIHC. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in STOMACH.
