Cellular response to glucagon stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to glucagon stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IGBP1P1, LRRC71, and CCT4P2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucagon stimulus activity versus IGBP1P1 in OV (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IGBP1P1 →	+0.435	+0.156	<.001	<.001	3	4
CCRCC	LRRC71 →	+0.325	+0.097	<.001	.002	3	4
CCRCC	CCT4P2 →	+0.502	+0.105	.001	<.001	3	4
GBM	SNRPC →	-0.296	-0.159	.002	.003	3	3
GBM	MRPS25 →	+0.214	+0.100	.003	.009	3	3
GBM	MAP3K12 →	+0.411	+0.184	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071377 vs IGBP1P1 — OV

Explore this scatter interactively →