Cellular response to glucagon stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to glucagon stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPG, PRXL2B, and TIMM10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucagon stimulus activity versus NCAPG in BREAST (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NCAPG →	+0.880	+0.250	.007	.004	3	4
SKIN	PRXL2B →	+1.011	+0.220	<.001	.002	3	4
BREAST	TIMM10 →	+0.679	+0.308	<.001	<.001	3	4
BLOOD_Lymphoma	RSBN1 →	+0.524	+0.222	.003	.004	3	3
STOMACH	PHF14 →	+0.894	+0.212	.007	.004	3	3
STOMACH	AJUBA →	-1.938	-0.231	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071377 vs NCAPG — BREAST

Explore this scatter interactively →