Cellular response to glucagon stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to glucagon stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC16A_S1305, RPRD1A, and ASS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to glucagon stimulus activity versus SEC16A_S1305 in LUAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEC16A_S1305 →	+0.522	+0.101	.003	.001	3	5
LSCC	RPRD1A →	-0.416	-0.118	.002	.003	3	5
UCEC	ASS1 →	+1.037	+0.163	<.001	<.001	3	5
GBM	TNKS1BP1_T131 →	+0.404	+0.077	<.001	.002	3	5
GBM	TRIP10 →	+0.354	+0.088	<.001	<.001	3	5
BRCA	ERO1A →	+0.487	+0.082	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0071377 vs SEC16A_S1305 — LUAD

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