Cellular response to glucagon stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to glucagon stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS13, GNPTAB, and THG1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPS13 grouped by Cellular response to glucagon stimulus-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RPS13 →	-0.664	-0.305	<.001	.002	3	4
SKIN	GNPTAB →	+1.085	+0.296	<.001	.008	3	4
BLOOD_Leukemia	THG1L →	-0.814	-0.321	.003	.008	3	3
BLOOD_Leukemia	ELF1 →	+1.067	+0.827	<.001	.002	3	3
KIDNEY	ZC3H13 →	+0.681	+0.636	.001	.001	3	3
KIDNEY	PRPF8 →	+0.725	+0.793	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPS13 by Cellular response to glucagon stimulus activity — SKIN

Explore this box plot interactively →